Compared to Shelter 17, Shelter 52 is built with a more urban design. Instead of placing the number of the shelter on an awning above the main door the same way Shelter 17 and Happy Valley does, the number "52" is incorporated into the sign, a blue collar with a gold tag, above the where the awning would be. The sign above the building bears the brown silhouette of what appears to be a doberman. The building itself is made up of brown brick with what seem to be white drainage pipes.
In "The Road to Empawerment", the shelter was "motivational speaker" Bony Doggins stop after Shelter 17. Niblet, Stuffy, Schleppy and Axel met up with Doggins outside of the shelter to ask him about how they could meet the Doggy Lama. Incidentally, the road right in front of the shelter leads right to the mountain that the Doggie Lama lives on.
The exterior of the shelter also appeared as the background to Strudel's character profile picture on HubWorld.com before the website was rebranded as HubNetwork.com in January 2014. Despite this, Strudel has no in-universe affiliation with Shelter 52, nor has she ever appeared in front of it on the show.Strudel's HubWorld PictureCupcake with two Pound Puppies of Shelter 52.Bony walking from the shelter.Schleppy, Stuffy, Axel, Niblet and Bony Doggins walking away from Shelter 52.